Pharmacokinetics Sildenafil:
The onset of action: 60 minutes
duration: 2-4 hours
Absorption: rapid, slower with a high-fat meal
Distribution: Vdss: 105 L
Protein binding, plasma: 96% Metabolism: Hepatic via CYP3A4 (MAJOR AND cyp2c9 ( minor route)
Bioavailability: 40%
Half-life elimination: 4 Hours
Time To Peak: 30-120 minutes; delayed by 60 minutes with a high-fat meal.
Erectile Dysfunction in Premature Ejaculation - Long Lost Night Tablet in Pakistan Part of the physiological process of erection involves the parasympathetic nervous system causing the release of nitric oxide (NO) in the Corpus cavernosum of the penis. No binds to the receptors of the enzyme guanylate cyclase which results in increased levels of cyclic guanosine monophosphate (cGMP), Leading To Smooth Muscle Relaxation (vasodilation) in the corpuscavernosum, resulting in increased inflow of blood and an erection.
Long Lost Night Tablet Dapoxetine 60mg Tablet is rapidly absorbed after oral administration with a peak plasma concentration (Tmaxx) occurring between 1.4 and 2.0 hours. this is followed by a rapid decline in plasma concentration, to about 5% of peak increased proportionately with doses up to 100 mg. The mean initial half-life of dapoxetine after a single dose is 0.5 to 0.8 hours and this decreased slightly to 0.4 to 0.6 hours after multiple doses for 6 days. the terminal half-life of dapoxetine was 15 to 19 pairs after a single dose and 20 to 24 after multiple doses. dapoxetine undergoes hepatic metabolism to 2 metabolites,
Sildenafil is a potent and selective inhibitor of cGMP specific phosphodiesterase type 5 (PDE5) which is responsible for the degradation of cGMP in the corpus cavernosum. the molecular structure of Sildenafil id similar to that of cGMP and acts as a competitive binding agent of PDE5 I=in the corpus cavernosum, resulting in more cGMP and better erections.
Dapoxetine Tablets exhibits its efficacy by primarily inhibiting the reuptake of the serotonin transporter. It was also shown to bind and inhibit the reuptake transporters of dopamine & norepinephrine.
Which are Long Lost Dapoxetine Side Effects?
Dapoxetine treatment is not without major side effects, however, these included: Nausea, Headache, Diarrhea, Dizziness.
How to Take Long Lost Night Tablet?
Take 1 Tablet 1-2 Hours before sexual intercourse with warm water
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